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Their effect is more general through the receptors for advanced glycation end products (RAGE), which are concentrated in the heart, lungs, and skeletal muscles
In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist
First introduced as an anticonvulsant for the treatment of epilepsy, gabapentins therapeutic scope has expanded considerably due to its efficacy in managing various types of neuropathic pain and other conditions
The failure of the Exenatide-PD3 and NLY01 trials has cast serious doubt on whether GLP-1 RAs have a future in PD
If you are pregnant or planning pregnancy, this requires specific consideration